反应详情

3.23 g (7.38 mmol) of the compound from Example 182A were initially charged in 60 ml of dichloromethane and, at RT, reacted with 5.7 ml (8.42 g, 73.8 mmol) of trifluoroacetic acid. The reaction mixture was stirred at RT for 16 h and then concentrated under reduced pressure. The residue was taken up in ethyl acetate, washed with saturated aqueous sodium bicarbonate solution, dried over magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 2.48 g (92% of theory)

1. concentrationconcentrated under reduced pressure
2. washwashed with saturated aqueous sodium bicarbonate solution
3. dry with materialdried over magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure