HRID1642852

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734645

Boc-cycloleucine

C11H19NO4

结构：FC(F)(F)c1ccc(C2CNCC(c3nc(C4CC4)no3)C2)cc1

HCID58002519

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC1(C(=O)N2CC(c3ccc(C(F)(F)F)cc3)CC(c3nc(C4CC4)no3)C2)CCCC1

HCID58002603

未命名化合物

PROCEDURE

实验过程

100 mg (0.30 mmol) of the compound from Example 183A and 75 mg (0.33 mmol) of 1-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid were reacted according to the General Method 7. Yield: 127 mg (78% of theory)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b87f603d83fe459baeef3d668cc2088f
来源数据集: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08119663B2
来源说明: uspto-grants-2012_02

反应 SMILES

[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=4)[CH2:12][NH:11][CH2:10]3)[O:6][N:5]=2)[CH2:3][CH2:2]1.[C:25]([O:29][C:30]([NH:32][C:33]1([C:38](O)=[O:39])[CH2:37][CH2:36][CH2:35][CH2:34]1)=[O:31])([CH3:28])([CH3:27])[CH3:26]>>[C:25]([O:29][C:30](=[O:31])[NH:32][C:33]1([C:38]([N:11]2[CH2:12][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:19][CH:20]=3)[CH2:14][CH:9]([C:7]3[O:6][N:5]=[C:4]([CH:1]4[CH2:2][CH2:3]4)[N:8]=3)[CH2:10]2)=[O:39])[CH2:37][CH2:36][CH2:35][CH2:34]1)([CH3:28])([CH3:26])[CH3:27]