HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-tert-Butoxycarbonylaminocyclopentanecarboxylic acid → Tert-butyl[1-({3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)cyclopentyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-tert-Butoxycarbonylaminocyclopentanecarboxylic acid | HCID 2734645 | — |
| Reactant | 3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidine | HCID 58002519 | — |
| Product | Tert-butyl[1-({3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)cyclopentyl]carbamate | HCID 58002603 | — |
Reaction Steps
100 mg (0.30 mmol) of the compound from Example 183A and 75 mg (0.33 mmol) of 1-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid were reacted according to the General Method 7. Yield: 127 mg (78% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-b87f603d83fe459baeef3d668cc2088f |
| Source note | uspto-grants-2012_02 |