HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloroacetone → {3-[4-(Chloromethyl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloroacetone | HCID 10793 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide | HCID 58002319 | — |
| Product | {3-[4-(Chloromethyl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}(morpholin-4-yl)methanone | HCID 58002555 | — |
Reaction Steps
250 mg (about 0.44 mmol) of the compound from Example 53A and 60 mg (0.52 mmol) of 1,3-dichloropropan-2-one were reacted according to the General Method 3. Yield: 150 mg (12% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-b29633b62535415bb321cc8e42102f46 |
| Source note | uspto-grants-2012_02 |