3-chloro-4-fluoro-N-hydroxy-benzenecarboximidamide → HCID 58002409, compound

HRID 1642883Notes

Reaction equation

HRID 1642883 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](O)=[O:24])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[Cl:26][C:27]1[CH:28]=[C:29]([C:34](=[N:36]O)[NH2:35])[CH:30]=[CH:31][C:32]=1[F:33]>>[Cl:26][C:27]1[CH:28]=[C:29]([C:34]2[N:36]=[C:23]([CH:11]3[CH2:10][CH:9]([C:6]4[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=4)[CH2:14][N:13]([C:15]([N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[O:16])[CH2:12]3)[O:24][N:35]=2)[CH:30]=[CH:31][C:32]=1[F:33]

Participants

3

Reactant 2

HCID 44117393-chloro-4-fluoro-N-hydroxy-benzenecarboximidamideHCID 580022255-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid

Product 1

HCID 58002409HCID 58002409, compound

Procedure

69 mg (0.20 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid (Example 38A) and 41 mg (0.22 mmol, 1.1 eq.) of 3-chloro-4-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 51 mg (51% of theory)

Sources & evidence

ORD record
ord-2ee1a524658f46d4b121392c08549756
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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