N'-Hydroxycyclopropanecarboximidamide → 1-{[3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(3,4-dimethylphenyl)piperidin-1-yl]carbonyl}-piperidine-4-carbonitrile

HRID 1642993Notes

Reaction equation

HRID 1642993 reaction equation
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([CH3:24])[CH:18]=3)[CH2:14][CH:13]([C:25](O)=[O:26])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].O[N:29]=[C:30]([CH:32]1[CH2:34][CH2:33]1)[NH2:31]>>[CH:32]1([C:30]2[N:31]=[C:25]([CH:13]3[CH2:14][CH:15]([C:17]4[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([CH3:24])[CH:18]=4)[CH2:16][N:11]([C:9]([N:6]4[CH2:5][CH2:4][CH:3]([C:1]#[N:2])[CH2:8][CH2:7]4)=[O:10])[CH2:12]3)[O:26][N:29]=2)[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 2794666N'-HydroxycyclopropanecarboximidamideHCID 58002563HCID 58002563, compound

Product 1

HCID 580025731-{[3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(3,4-dimethylphenyl)piperidin-1-yl]carbonyl}-piperidine-4-carbonitrile

Procedure

80 mg (0.21 mmol) of the compound from Example 132A and 32 mg (0.32 mmol) of N′-hydroxycyclopropanimidamide were reacted according to the General Method 2. Yield: 41 mg (45% of theory)

Sources & evidence

ORD record
ord-58d7ec6d653c45f28bdb36b1f329c42b
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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