HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxycyclopropanecarboximidamide → 1-{[3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(3,4-dimethylphenyl)piperidin-1-yl]carbonyl}-piperidine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxycyclopropanecarboximidamide | HCID 2794666 | — |
| Reactant | HCID 58002563 | HCID 58002563 | — |
| Product | 1-{[3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(3,4-dimethylphenyl)piperidin-1-yl]carbonyl}-piperidine-4-carbonitrile | HCID 58002573 | — |
Reaction Steps
80 mg (0.21 mmol) of the compound from Example 132A and 32 mg (0.32 mmol) of N′-hydroxycyclopropanimidamide were reacted according to the General Method 2. Yield: 41 mg (45% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-58d7ec6d653c45f28bdb36b1f329c42b |
| Source note | uspto-grants-2012_02 |