HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-fluoro-N'-hydroxybenzene-1-carboximidamide → {3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-fluoro-N'-hydroxybenzene-1-carboximidamide | HCID 4090972 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[3-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid | HCID 58002149 | — |
| Product | {3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone | HCID 58002328 | — |
Reaction Steps
100 mg (0.26 mmol) of the compound from Example 147A and 60 mg (0.39 mmol) of the compound from Example 73A were reacted according to the General Method 2. Yield: 75 mg (57% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-6a93d1b339604641b9b6b6c67658667b |
| Source note | uspto-grants-2012_02 |