N'-hydroxy-2-propan-2-ylsulfonylethanimidamide → [3-(3,4-Dimethylphenyl)-5-[3-[(propan-2-ylsulphonyl)methyl]-1,2,4-oxadiazol-5-yl]piperidin-1-yl](morpholin-4-yl)methanone

HRID 1643001Notes

Reaction equation

HRID 1643001 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](O)=[O:24])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].O[N:27]=[C:28]([NH2:36])[CH2:29][S:30]([CH:33]([CH3:35])[CH3:34])(=[O:32])=[O:31]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:10][CH:11]([C:23]3[O:24][N:36]=[C:28]([CH2:29][S:30]([CH:33]([CH3:35])[CH3:34])(=[O:32])=[O:31])[N:27]=3)[CH2:12][N:13]([C:15]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)=[O:16])[CH2:14]2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 2819602N'-hydroxy-2-propan-2-ylsulfonylethanimidamideHCID 58002579HCID 58002579, compound

Product 1

HCID 58002219[3-(3,4-Dimethylphenyl)-5-[3-[(propan-2-ylsulphonyl)methyl]-1,2,4-oxadiazol-5-yl]piperidin-1-yl](morpholin-4-yl)methanone

Procedure

100 mg (0.289 mmol) of the compound from Example 130A and 78 mg (0.433 mmol) of N′-hydroxy-2-(propan-2-ylsulphonyl)ethanimidamide were reacted according to the General Method 2. Yield: 108 mg (75% of theory)

Sources & evidence

ORD record
ord-9f9a78aa53444130b21f96f46f7dbfaa
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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