N-Hydroxyacetamidine → [3-(3,4-Dimethylphenyl)-5-(3-methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl] (morpholin-4-yl)-methanone
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](O)=[O:24])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].O[N:27]=[C:28]([NH2:30])[CH3:29]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:10][CH:11]([C:23]3[O:24][N:30]=[C:28]([CH3:29])[N:27]=3)[CH2:12][N:13]([C:15]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)=[O:16])[CH2:14]2)[CH:5]=[CH:6][C:7]=1[CH3:8]Participants
3
Procedure
100 mg (0.29 mmol) of the compound from Example 130A and 33 mg (0.43 mmol) of N′-hydroxyacetamidine were reacted according to the General Method 2. Yield: 68 mg (61% of theory)
Sources & evidence
- ORD record
- ord-0ea2c94d6af54a60a0f26a4dd7b9b9a8
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08119663B2
Reaction notes
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