1-(Dimethylamino)cyclopropanecarboxylicacid → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}[1-(dimethyl-amino)cyclopropyl]methanone

HRID 1643011Notes

Reaction equation

HRID 1643011 reaction equation
[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=4)[CH2:12][NH:11][CH2:10]3)[O:6][N:5]=2)[CH2:3][CH2:2]1.[CH3:25][N:26]([CH3:33])[C:27]1([C:30](O)=[O:31])[CH2:29][CH2:28]1>>[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:19][CH:20]=4)[CH2:12][N:11]([C:30]([C:27]4([N:26]([CH3:33])[CH3:25])[CH2:29][CH2:28]4)=[O:31])[CH2:10]3)[O:6][N:5]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 3861991-(Dimethylamino)cyclopropanecarboxylicacidHCID 580025193-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidine

Product 1

HCID 58002541{3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}[1-(dimethyl-amino)cyclopropyl]methanone

Procedure

100 mg (0.30 mmol) of the compound from Example 183A and 42 mg (0.33 mmol) of 1-(dimethylamino)cyclopropanecarboxylic acid were reacted according to the General Method 7. Yield: 120 mg (90% of theory)

Sources & evidence

ORD record
ord-55d1d4c827e94cef98f0af5cc0b70421
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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