HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Dimethylamino)cyclopropane-1-carboxylic acid → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}[1-(dimethyl-amino)cyclopropyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Dimethylamino)cyclopropane-1-carboxylic acid | HCID 386199 | — |
| Reactant | 3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidine | HCID 58002519 | — |
| Product | {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}[1-(dimethyl-amino)cyclopropyl]methanone | HCID 58002541 | — |
Reaction Steps
100 mg (0.30 mmol) of the compound from Example 183A and 42 mg (0.33 mmol) of 1-(dimethylamino)cyclopropanecarboxylic acid were reacted according to the General Method 7. Yield: 120 mg (90% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-55d1d4c827e94cef98f0af5cc0b70421 |
| Source note | uspto-grants-2012_02 |