Pyrrolidin-3-amine--hydrogen chloride (1/1) → (3-Aminopyrrolidin-1-yl) {3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]-piperidin-1-yl}methanone

HRID 1643021Notes

Reaction equation

HRID 1643021 reaction equation
[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=4)[CH2:12][N:11]([C:26](OC4C=CC([N+]([O-])=O)=CC=4)=[O:27])[CH2:10]3)[O:6][N:5]=2)[CH2:3][CH2:2]1.Cl.[NH2:39][CH:40]1[CH2:44][CH2:43][NH:42][CH2:41]1>>[NH2:39][CH:40]1[CH2:44][CH2:43][N:42]([C:26]([N:11]2[CH2:12][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([O:21][C:22]([F:24])([F:25])[F:23])=[CH:19][CH:20]=3)[CH2:14][CH:9]([C:7]3[O:6][N:5]=[C:4]([CH:1]4[CH2:3][CH2:2]4)[N:8]=3)[CH2:10]2)=[O:27])[CH2:41]1

Participants

3

Reactant 2

HCID 24206432Pyrrolidin-3-amine--hydrogen chloride (1/1)HCID 580026324-Nitrophenyl 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxylate

Product 1

HCID 58002726(3-Aminopyrrolidin-1-yl) {3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]-piperidin-1-yl}methanone

Procedure

90 mg (0.17 mmol) of the compound from Example 176A and 83 mg (0.52 mmol) of 3-aminopyrrolidine hydrochloride were reacted according to the General Method 6. Yield: 13 mg (15% of theory)

Sources & evidence

ORD record
ord-b47d1f48c0d34cfc96bfb963838dea65
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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