HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidin-3-amine--hydrogen chloride (1/1) → (3-Aminopyrrolidin-1-yl) {3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]-piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidin-3-amine--hydrogen chloride (1/1) | HCID 24206432 | — |
| Reactant | 4-Nitrophenyl 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxylate | HCID 58002632 | — |
| Product | (3-Aminopyrrolidin-1-yl) {3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]-piperidin-1-yl}methanone | HCID 58002726 | — |
Reaction Steps
90 mg (0.17 mmol) of the compound from Example 176A and 83 mg (0.52 mmol) of 3-aminopyrrolidine hydrochloride were reacted according to the General Method 6. Yield: 13 mg (15% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-b47d1f48c0d34cfc96bfb963838dea65 |
| Source note | uspto-grants-2012_02 |