N-Hydroxyacetamidine → HCID 58002560, compound

HRID 1643023Notes

Reaction equation

HRID 1643023 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26](O)=[O:27])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O[N:30]=[C:31]([NH2:33])[CH3:32]>>[CH3:32][C:31]1[N:33]=[C:26]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:23])[F:24])=[CH:17][CH:16]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[O:27][N:30]=1

Participants

3

Reactant 2

HCID 30926N-HydroxyacetamidineHCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002560HCID 58002560, compound

Procedure

200 mg (0.50 mmol) of the compound from Example 44A and 74 mg (0.75 mmol) of N′-hydroxyethanimidamide were reacted according to the General Method 2. Yield: 119 mg (52% of theory)

Sources & evidence

ORD record
ord-ba496614a06749a2aed98c8f423df73f
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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