N-Hydroxynicotinimidamide → HCID 58002615, compound

HRID 1643074Notes

Reaction equation

HRID 1643074 reaction equation
[OH:1][CH:2]1[CH2:5][N:4]([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:24](O)=[O:25])[CH2:9]2)=[O:7])[CH2:3]1.O[N:28]=[C:29]([C:31]1[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=1)[NH2:30]>>[OH:1][CH:2]1[CH2:3][N:4]([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:15]=[CH:16][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:18][CH:19]=3)[CH2:11][CH:10]([C:24]3[O:25][N:30]=[C:29]([C:31]4[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=4)[N:28]=3)[CH2:9]2)=[O:7])[CH2:5]1

Participants

3

Reactant 2

HCID 308113N-HydroxynicotinimidamideHCID 580025781-[(3-Hydroxyazetidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002615HCID 58002615, compound

Procedure

100 mg (0.269 mmol) of 1-[(3-hydroxyazetidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid (Example 101A) and 40.5 mg (0.295 mmol) of N′-hydroxypyridine-3-carboximidamide were reacted according to the General Method 1. Yield: 28.8 mg (21% of theory).

Sources & evidence

ORD record
ord-439e1bd7df754a8cb059eeb06e2bf2f6
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

Loading…