N-Hydroxyacetamidine → HCID 58002452, compound

HRID 1643119Notes

Reaction equation

HRID 1643119 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:27](O)=[O:28])[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:31]=[C:32]([NH2:34])[CH3:33]>>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:24])([F:26])[F:25])=[CH:18][CH:17]=3)[CH2:13][CH:12]([C:27]3[O:28][N:34]=[C:32]([CH3:33])[N:31]=3)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 30926N-HydroxyacetamidineHCID 580024151-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002452HCID 58002452, compound

Procedure

200 mg (0.480 mmol) of the compound from Example 63A and 71 mg (0.961 mmol) of N′-hydroxyethanimidamide were reacted according to the General Method 2. Yield: 144 mg (62% of theory)

Sources & evidence

ORD record
ord-2c27e9e518864f9a9c2e9a3b1e5f4f1a
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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