HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylbutanehydrazide → {3-[5-(2-Methylpropyl)-1,3,4-oxadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylbutanehydrazide | HCID 32283 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002500 | — |
| Product | {3-[5-(2-Methylpropyl)-1,3,4-oxadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone | HCID 58002336 | 36.6% |
Reaction Steps
100 mg (0.249 mmol) of the compound from Example 44A and 32 mg (0.273 mmol) of 3-methylbutanehydrazide were reacted according to the General Method 4. Diastereomer separation of the cis/trans isomer mixture according to Method 14C gave 44 mg of the title compound (cis isomer) and 12 mg of the trans isomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-473325ed2b5242cc97fff157aa5cae52 |
| Source note | uspto-grants-2012_02 |