1-Bromo-2-butanone → HCID 58002359, compound

HRID 1643130Notes

Reaction equation

HRID 1643130 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25](=[S:27])[NH2:26])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:29][C:30](=O)[CH2:31][CH3:32]>>[CH2:31]([C:30]1[N:26]=[C:25]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[S:27][CH:29]=1)[CH3:32]

Participants

3

Reactant 2

HCID 131561-Bromo-2-butanoneHCID 580023191-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide

Product 1

HCID 58002359HCID 58002359, compound

Procedure

220 mg (about 0.384 mmol) of the compound from Example 53A and 70 mg (0.460 mmol) of 1-bromobutan-2-one were reacted according to the General Method 3. Yield: 63 mg (36% of theory).

Sources & evidence

ORD record
ord-1ae0d94b2fd34edc9ba5008265714873
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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