Lawesson's reagent → {3-[5-(2-Methoxyethyl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

HRID 1643142Notes

Reaction equation

HRID 1643142 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]([NH:7][NH:8][C:9]([CH:11]1[CH2:16][CH:15]([C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=2)[CH2:14][N:13]([C:28]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[O:29])[CH2:12]1)=O)=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:45])=CC=1>>[CH3:1][O:2][CH2:3][CH2:4][C:5]1[S:45][C:9]([CH:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[CH2:14][N:13]([C:28]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[O:29])[CH2:12]2)=[N:8][N:7]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 58002538N'-(3-Methoxypropanoyl)-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide

Product 1

HCID 58002723{3-[5-(2-Methoxyethyl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

Procedure

93 mg (0.185 mmol) of the compound from Example 120A and 150 mg (0.371 mmol) of Lawesson reagent were reacted according to the General Method 9. Yield: 9 mg (10% of theory)

Sources & evidence

ORD record
ord-73c848acb76f42f29d76ce179e21ea1d
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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