HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → {3-[5-(2-Methoxyethyl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | N'-(3-Methoxypropanoyl)-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide | HCID 58002538 | — |
| Product | {3-[5-(2-Methoxyethyl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone | HCID 58002723 | — |
Reaction Steps
93 mg (0.185 mmol) of the compound from Example 120A and 150 mg (0.371 mmol) of Lawesson reagent were reacted according to the General Method 9. Yield: 9 mg (10% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-73c848acb76f42f29d76ce179e21ea1d |
| Source note | uspto-grants-2012_02 |