Lawesson's reagent → Morpholin-4-yl {3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}methanone

HRID 1643144Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1643144
[CH3:1][CH:2]([CH3:34])[C:3]([NH:5][NH:6][C:7]([CH:9]1[CH2:14][CH:13]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)[CH2:12][N:11]([C:26]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[O:27])[CH2:10]1)=O)=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:44])=CC=1>>[N:28]1([C:26]([N:11]2[CH2:12][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:14][CH:9]([C:7]3[S:44][C:3]([CH:2]([CH3:34])[CH3:1])=[N:5][N:6]=3)[CH2:10]2)=[O:27])[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1

Komponenten

3

Edukt 2

HCID 87949Lawesson's reagentHCID 58002287N'-(2-Methylpropanoyl)-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide

Produkt 1

HCID 58002533Morpholin-4-yl {3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}methanone

Versuchsvorschrift

79 mg (0.155 mmol) of the compound from Example 122A and 126 mg (0.310 mmol) of Lawesson reagent were reacted according to the General Method 9. Yield: 17 mg (22% of theory)

Quellen und Nachweise

ORD-Eintrag
ord-7f4f48cf55514f11a476edec860e23e8
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08119663B2

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