HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → Morpholin-4-yl {3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | N'-(2-Methylpropanoyl)-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide | HCID 58002287 | — |
| Product | Morpholin-4-yl {3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}methanone | HCID 58002533 | — |
Reaction Steps
79 mg (0.155 mmol) of the compound from Example 122A and 126 mg (0.310 mmol) of Lawesson reagent were reacted according to the General Method 9. Yield: 17 mg (22% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-7f4f48cf55514f11a476edec860e23e8 |
| Source note | uspto-grants-2012_02 |