HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → Morpholin-4-yl {3-(5-phenyl-1,3,4-thiadiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-N'-(phenylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide | HCID 58002666 | — |
| Product | Morpholin-4-yl {3-(5-phenyl-1,3,4-thiadiazol-2-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-methanone | HCID 58002639 | — |
Reaction Steps
132 mg (0.239 mmol) of the compound from Example 123A and 193 mg (0.478 mmol) of Lawesson reagent were reacted according to the General Method 9. Yield: 40 mg (32% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-a3e1c2c8058847bd9faaa78e962c6ab9 |
| Source note | uspto-grants-2012_02 |