N-Hydroxypicolinimidamide → Morpholin-4-yl{3-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}methanone

HRID 1643170Notes

Reaction equation

HRID 1643170 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25]([OH:27])=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O[N:29]=[C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=1)[NH2:31]>>[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:19][CH:20]=3)[CH2:12][CH:11]([C:25]3[O:27][N:31]=[C:30]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=4)[N:29]=3)[CH2:10]2)=[O:8])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 120564N-HydroxypicolinimidamideHCID 580024471-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002477Morpholin-4-yl{3-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}methanone

Procedure

250 mg (about 0.520 mmol) of the compound from Example 49A and 79 mg (0.580 mmol) of N′-hydroxypyridine-2-carboximidamide (Example 69A) were reacted according to the General Method 1. Yield: 49 mg (19% of theory).

Sources & evidence

ORD record
ord-475db1a339fa4e21977a10abb93db41a
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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