HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxypicolinimidamide → Morpholin-4-yl{3-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxypicolinimidamide | HCID 120564 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid | HCID 58002447 | — |
| Product | Morpholin-4-yl{3-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}methanone | HCID 58002477 | — |
Reaction Steps
250 mg (about 0.520 mmol) of the compound from Example 49A and 79 mg (0.580 mmol) of N′-hydroxypyridine-2-carboximidamide (Example 69A) were reacted according to the General Method 1. Yield: 49 mg (19% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-475db1a339fa4e21977a10abb93db41a |
| Source note | uspto-grants-2012_02 |