反应详情

60 mg (0.23 mmol) of 3-fluoro-4-[(3-methyl-1H-indazol-4-yl)oxy]phenylamine (from example III) and 48 mg (0.23 mmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) are suspended in 4 ml of water, and 0.02 ml of concentrated hydrochloric acid is added. The reaction mixture is heated at reflux overnight, resulting in the formation of a brown precipitate. This is filtered off, washed repeatedly with water and dried under high vacuum. This gives 65 mg (65% of theory) of the product as a brown solid.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux overnight
3. customresulting in the formation of a brown precipitate
4. filtrationThis is filtered off
5. washwashed repeatedly with water
6. customdried under high vacuum