Trifluoroacetic acid → Trifluoroacetic acid

HRID 1643251Notes

Reaction equation

HRID 1643251 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([O:15][CH2:16][CH3:17])=[CH:10][C:9]=1[CH3:18])(C)(C)C.[F:20][C:21]([F:26])([F:25])[C:22]([OH:24])=[O:23]>ClCCl>[CH2:16]([O:15][C:11]1[C:12]([CH3:14])=[CH:13][C:8]([NH2:7])=[C:9]([CH3:18])[CH:10]=1)[CH3:17].[C:22]([OH:24])([C:21]([F:26])([F:25])[F:20])=[O:23]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66758388HCID 66758388, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 201095224-Ethoxy-2,5-dimethylaniline

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 36 (950 mg, 3.6 mmol) in 10 mL dichoromethane, trifloroacetic acid (5 mL) was added. The reaction mixture was stirred for 2 h. At this point, LC-MS showed the reaction to be complete. The reaction flask was concentrated to remove the solvent and most of the TFA. The residue was then dried further in a high vacuum oven over 24 h to give the title compound 37 as TFA salt.

Workup

  1. customthe reaction
  2. concentrationThe reaction flask was concentrated
  3. customto remove the solvent
  4. customThe residue was then dried further in a high vacuum oven over 24 h

Sources & evidence

ORD record
ord-d0b47e58c47f467dacf4060e7c468e7b
Source dataset
uspto-grants-2012_02
Patent number
US08119680B2

Reaction notes

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