反应详情

温度

25 °C

To the solution of 4R)-4-(4-fluoro-3-methylphenyl)-4-methoxy-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (66 mg, 0.2 mmol) in 4 mL DCM was slowly added 2 mL TFA and the resulting solution stirred for 30 min at 25° C. The solvent was evaporated and the product isolated by flash column chromatography eluting with 0% to 10% methanol/DCM gradient solvent to give 32 mg of the title compound as a white solid.

1. customThe solvent was evaporated
2. customthe product isolated by flash column chromatography
3. washeluting with 0% to 10% methanol/DCM gradient solvent