反应详情

温度

40 °C

To a solution of (R)-methyl 4-(4-fluorophenyl)-4-hydroxybutanoate (1.7 g, 8.0 mmol) in DCM (40 mL) was added 8 drops TFA at room temperature. The reaction mixture was warmed to 40° C. and stirred for 16 h. Evaporation of the solvent gave a light yellow oil from which the product was isolated by Flash chromatography eluting with 0% to 30% ethyl acetate/hexane to give 1.6 g of the title compound as a colorless oil.

1. customEvaporation of the solvent
2. customgave a light yellow oil from which the product
3. customwas isolated by Flash chromatography
4. washeluting with 0% to 30% ethyl acetate/hexane