反应详情

To a solution of (2S)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-(tetrahydro-2H-pyran-2-yloxy)hexanamide (43 mg, 0.12 mmol) in 3 mL DCM was slowly added 3 mL TFA followed by stirring for 30 min at room temperature. The solvent was evaporated and the product isolated by flash column chromatography eluting with 0% to 10% methanol/DCM to give 26 mg of the title compound as white solid.

1. customThe solvent was evaporated
2. customthe product isolated by flash column chromatography
3. washeluting with 0% to 10% methanol/DCM