(R)-Methyl 4-(4-fluoro-3-methylphenyl)-4-hydroxybutanoate → (R)-5-(4-fluoro-3-methyl-phenyl)-dihydro-furan-2-one

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-methyl 4-(4-fluoro-3-methyl-phenyl)-4-hydroxy-butanoate (289 mg) in 20 mL DCM was added 4 drops TFA at room temperature and the resulting solution warmed to 40° C. After stirring for 16 h the reaction was cooled to room temperature and concentrated under reduced pressure. The product was isolated by flash column chromatograph eluting with 0% to 30% ethyl acetate/hexane gradient solvent to give 279 mg of (R)-5-(4-fluoro-3-methyl-phenyl)-dihydro-furan-2-one as a colorless oil.

Provenance & Evidence