反应详情

温度

40 °C

To a solution of (R)-methyl 4-(4-fluoro-3-methyl-phenyl)-4-hydroxy-butanoate (289 mg) in 20 mL DCM was added 4 drops TFA at room temperature and the resulting solution warmed to 40° C. After stirring for 16 h the reaction was cooled to room temperature and concentrated under reduced pressure. The product was isolated by flash column chromatograph eluting with 0% to 30% ethyl acetate/hexane gradient solvent to give 279 mg of (R)-5-(4-fluoro-3-methyl-phenyl)-dihydro-furan-2-one as a colorless oil.

1. temperaturewas cooled to room temperature
2. concentrationconcentrated under reduced pressure
3. customThe product was isolated by flash column chromatograph
4. washeluting with 0% to 30% ethyl acetate/hexane gradient solvent