Tetrahydrofuran → 2-Bromo-5-cyclopropyl-3-fluorobenzoic acid

HRID 164330Notes

Reaction equation

HRID 164330 reaction equation
[Br:19][C:20]([Cl:21])([Cl:22])[C:23]([Cl:24])([Cl:25])[Br:26].[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH:1]([Li:2])([CH2:3][CH3:4])[CH3:5].[CH:6]1([c:9]2[cH:10][c:11]([C:12](=[O:13])[OH:14])[cH:15][c:16]([F:18])[cH:17]2)[CH2:7][CH2:8]1>>[CH:6]1([c:9]2[cH:10][c:11]([C:12](=[O:13])[OH:14])[c:15]([Br:19])[c:16]([F:18])[cH:17]2)[CH2:7][CH2:8]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 694261,2-Dibromo-1,1,2,2-tetrachloroethaneHCID 673954473-Cyclopropyl-5-fluorobenzoic acidHCID 178418400CID 53628100

Product 1

HCID 584158362-Bromo-5-cyclopropyl-3-fluorobenzoic acid

Sources & evidence

ORD record
ord-8951a6af2dd6465dad0b30f377c0b714
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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