Sodium Hydroxide → HCID 66756617, compound

HRID 1643342Notes

Reaction equation

HRID 1643342 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:16]([S:27](=[O:34])(=[O:33])[N:28]([CH3:32])[CH2:29][CH2:30][CH3:31])=[CH:15][C:10]=1[C:11]([O:13]C)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO.C1COCC1>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]([O:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:16]([S:27](=[O:33])(=[O:34])[N:28]([CH3:32])[CH2:29][CH2:30][CH3:31])=[CH:15][C:10]=1[C:11]([OH:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 66756276HCID 66756276, compound

Product 1

HCID 66756617HCID 66756617, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

2.8 113 g of methyl 2,4-dibenzyloxy-5-(N-methyl-N-propylsulfamoyl)benzoate are dissolved in 300 ml of methanol and 300 ml of THF, 600 ml of 2 N NaOH are added, and the mixture is stirred at room temperature for 14 hours. Some of the solvent is removed, and the mixture is neutralised using dilute HCl with ice-cooling. The precipitated product is separated off and dried, giving 2,4-dibenzyloxy-5-(N-methyl-N-propylsulfamoyl)benzoic acid in quantitative yield.

Workup

  1. customSome of the solvent is removed
  2. temperaturecooling
  3. customThe precipitated product is separated off
  4. customdried

Sources & evidence

ORD record
ord-36142155cd3b4bff884aa55f3f6691ce
Source dataset
uspto-grants-2012_02
Patent number
US08119795B2

Reaction notes

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