反应详情

100 mg (0.39 mmol) of 4-(4-amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine (from example VII) and 63.3 mg (0.39 mmol) of 2-amino-4,6-dichloropyrimidine are suspended in 3 ml of water, and 0.04 ml of concentrated hydrochloric acid is added. The reaction mixture is heated at reflux overnight, resulting in the formation of a colorless precipitate. This is filtered off, washed repeatedly with water and dried under high vacuum.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux overnight
3. customresulting in the formation of a colorless precipitate
4. filtrationThis is filtered off
5. washwashed repeatedly with water
6. customdried under high vacuum