Thionyl Chloride → HCID 59367748, compound

HRID 1643469Notes

Reaction equation

HRID 1643469 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([S:9]([N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[CH2:18][S:19](O)(=[O:21])=[O:20])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:27])=O>C1C=CC=CC=1>[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([S:9]([N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[CH2:18][S:19]([Cl:27])(=[O:21])=[O:20])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 59367735(1-(3-(Trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methanesulfonic acid

Product 1

HCID 59367748HCID 59367748, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

(1-(3-(Trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methanesulfonic acid was dissolved in benzene (3 ml), thionyl chloride (0.034 ml) was added and the mixture was refluxed for 4 h. After cooling, the reaction mixture was concentrated in vacuo and the crude product was employed in the next stage without purification.

Workup

  1. temperaturethe mixture was refluxed for 4 h
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated in vacuo
  4. customthe crude product was employed in the next stage without purification

Sources & evidence

ORD record
ord-2af1122ebe1548349e7499d8627e79b4
Source dataset
uspto-grants-2012_02
Patent number
US08119805B2

Reaction notes

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