HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (1-(3-(Trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methanesulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (1-(3-(Trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methanesulfonic acid | HCID 59367735 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | (1-(3-(Trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methanesulfonyl chloride | HCID 59367748 | — |
Reaction Steps
(1-(3-(Trifluoromethyl)phenylsulfonyl)piperidin-2-yl)methanesulfonic acid was dissolved in benzene (3 ml), thionyl chloride (0.034 ml) was added and the mixture was refluxed for 4 h. After cooling, the reaction mixture was concentrated in vacuo and the crude product was employed in the next stage without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119805B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-2af1122ebe1548349e7499d8627e79b4 |
| Source note | uspto-grants-2012_02 |