Hydrogen Cyanide → L-Methionine

HRID 1643529Notes

Reaction equation

[CH3:1][S:2][CH2:3][CH2:4][CH:5]=O.C#[N:8].[C:9](=[O:12])([O-])[O-:10].[NH4+].[NH4+]>>[NH2:8][C@H:5]([C:9]([OH:10])=[O:12])[CH2:4][CH2:3][S:2][CH3:1]

Participants

Reactant 3

HCID 768Hydrogen Cyanide

HCID 18635Methional

HCID 517111Ammonium Carbonate

Product 1

HCID 6137L-Methionine

Procedure

As a process for producing methionine, a process in which a raw material, 3-methylthiopropanal is reacted with hydrogen cyanide in the presence of a base (a cyanohydrination step); subsequently, the resulting product is reacted with ammonium carbonate (a hydantoination step); and then the resulting product is hydrolyzed to give methionine is widely known (see JP-A-2002-114758, JP-A-2002-105048, JP-A-2003-104958, JP-A-2003-104959, JP-A-2003-104960, JP-A-10-182593, JP-A-2003-119557, JP-A-11-217370 and JP-A-2007-314507).

Sources & evidence

ORD record: ord-b759db4057eb40d1b538a1ac78a39767
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119837B2

Reaction notes

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