4-Chloro-1-(chloromethyl)-2-nitrobenzene → 4-Chloro-2-nitro-DL-phenylalanine

HRID 1643885Notes

Reaction equation

HRID 1643885 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Cl)=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.C(C(CC)C([NH:18][CH:19](C([O-])=O)[C:20]([O-:22])=[O:21])=O)C>>[NH2:18][CH:19]([CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][C:4]=1[N+:10]([O-:12])=[O:11])[C:20]([OH:22])=[O:21]

Participants

3

Reactant 2

HCID 5983994-Chloro-1-(chloromethyl)-2-nitrobenzeneHCID 21751412Diethylacetamidomalonate

Product 1

HCID 122325564-Chloro-2-nitro-DL-phenylalanine

Procedure

The title compound was prepared from 4-chloro-2-nitrobenzyl chloride and diethylacetamidomalonate according to the procedures described by Davis, A. L.; et al, in Arch. Biochem. Biophys., 102, 48 (1963).

Sources & evidence

ORD record
ord-44308ca3e23f46a0a52d653cf0a75ecf
Source dataset
uspto-grants-2012_02
Patent number
US08119808B2

Reaction notes

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