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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1643885Generated: November 1, 2026

4-Chloro-1-(chloromethyl)-2-nitrobenzene → 4-Chloro-2-nitro-DL-phenylalanine

https://huagongshe.com/reaction/1643885

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-1-(chloromethyl)-2-nitrobenzeneHCID 598399—
ReactantDiethylacetamidomalonateHCID 21751412—
Product4-Chloro-2-nitro-DL-phenylalanineHCID 12232556—

Reaction Steps

The title compound was prepared from 4-chloro-2-nitrobenzyl chloride and diethylacetamidomalonate according to the procedures described by Davis, A. L.; et al, in Arch. Biochem. Biophys., 102, 48 (1963).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08119808B2
Source datasetuspto-grants-2012_02
ORD IDord-44308ca3e23f46a0a52d653cf0a75ecf
Source noteuspto-grants-2012_02