反应详情

To a solution of 152A (1.0 g, 4.1 mmol) in 50% aqueous EtOH (40 mL), 10% Pt/C (100 mg) was added under argon and the mixture was hydrogenated at 35 psi for 1 h. The reaction mixture was filtered via a pad of celite and the filtrate was concentrated. The residue was dissolved in conc. HCl (10 mL) and stirred at RT for 6 h. The mixture was then concentrated and dissolved in 100 mL of saturated aqueous sodium bicarbonate. The white solid was filtered and dried to afford 0.44 g of 152B.

1. filtrationThe reaction mixture was filtered via a pad of celite
2. concentrationthe filtrate was concentrated
3. dissolutionThe residue was dissolved in conc. HCl (10 mL)
4. concentrationThe mixture was then concentrated
5. dissolutiondissolved in 100 mL of saturated aqueous sodium bicarbonate
6. filtrationThe white solid was filtered
7. customdried