反应详情

To a suspension of racemate 1G (313.4 mg, 1 mmol) in a mixed solvent of acetic acid (3 mL), THF (3 mL) and CH2Cl2 (3 mL) at RT was added benzyltrimethyl-ammonium tetrachloroiodate (419 mg, 1 mmol). After addition, the mixture was stirred at RT for 30 min to become a clear yellow solution which was concentrated in vacuo. The residue was triturated with CH2Cl2 and H2O and the resultant solid filtered and washed with CH2Cl2 and H2O, dried in vacuo to give the title compound as an off-white solid (204 mg, 59%).

1. additionAfter addition
2. concentrationwas concentrated in vacuo
3. customThe residue was triturated with CH2Cl2 and H2O
4. filtrationthe resultant solid filtered
5. washwashed with CH2Cl2 and H2O
6. customdried in vacuo