Water → (3-Fluoro-1,2-phenylene)dimethanol

HRID 1644009노트

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HRID 1644009 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:10]([C:11](O)=[O:12])[C:9]=1[C:17](O)=[O:18].[OH-].[Na+].O>C1COCC1>[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:10]([CH2:11][OH:12])[C:9]=1[CH2:17][OH:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 3453813-Fluorophthalic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 18402162(3-Fluoro-1,2-phenylene)dimethanol수율 79%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of LiAlH4 (1M in tetrahydrofuran) (54 ml, 54.0 mmol, 2.0 molar equivalents), cooled to −78° C., was added dropwise a solution of 3-fluorophtalic acid (5.0 g, 27.2 mmol, 1 molar equivalent) in THF (25 ml). The reaction mixture was allowed to warm up to room temperature and then stirred at 70° C. for 2 hours. To this resulting solution, cooled at 0° C. was added a 2M sodium hydroxide solution (25 ml) followed by cold water (25 ml) and THF (50 ml). The reaction mixture was then further extracted with THF (3×50 ml). The organic fractions were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuum to give a light yellow solid. Purification by recrystallisation from acetone/hexane gave the title compound as white needles (3.3 g, 79%). 1H NMR (300.13 MHz, DMSO) δ(ppm) 4.53 (dd, J1=5.50, J2=2.00 Hz, 2H) 4.67 (d, J=5.50 Hz, 2H) 4.98 (t, J=5.50 Hz, 1H) 5.22 (t, J=5.50 Hz, 1H) 7.00-7.10 (m, 1H) 7.25-7.35 (m, 2H). 19F NMR (282.38 MHz, DMSO) δ(ppm) −119.92 (s). 13C NMR (75.48 MHz, CDCl3) δ(ppm) 52.63, 60.07, 113.26, 122.81, 128.69, 144.02, 158.64, 161.87.

후처리

  1. temperatureTo this resulting solution, cooled at 0° C.
  2. extractionThe reaction mixture was then further extracted with THF (3×50 ml)
  3. washwashed with brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuum
  7. customto give a light yellow solid
  8. customPurification
  9. customby recrystallisation from acetone/hexane

출처 및 근거

ORD 기록
ord-71bf5c2d94714858a307106bcdc17c95
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119804B2

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