Bromoacetyl bromide → 865106-47-4

HRID 1644349Notes

Reaction equation

HRID 1644349 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[OH:10].Br[CH2:12][C:13](Br)=[O:14].O=C1NC2C=C(C#N)C=CC=2OC1>>[F:8][C:6]1[CH:5]=[C:4]([F:9])[C:3]2[O:10][CH2:12][C:13](=[O:14])[NH:1][C:2]=2[CH:7]=1

Participants

4

Reactant 3

HCID 61147Bromoacetyl bromideHCID 27376532-Amino-4,6-difluorophenolHCID 106548133-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonitrile

Product 1

HCID 55252814865106-47-4

Procedure

Commercially available 2-amino-4,6-difluorophenol (1 g, 6.9 mmol) and bromo acetyl bromide (0.9 mL, 10.3 mmol) were reacted according to the procedure for Intermediate 60 to afford the product as a solid, 208 mg (16%).

Sources & evidence

ORD record
ord-d03b1b8a11894f389ec3fc614921ffcb
Source dataset
uspto-grants-2012_02
Patent number
US08124602B2

Reaction notes

Loading…