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HRID1644363

反应详情

EQUATION

反应方程式

HRID 1644363 的结构方程式

REACTANTS

反应物

3
结构：[BH3-]C#N.[Na+]
HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：O=Cc1ccc2c(n1)NC(=O)CO2
HCID21873737

未命名化合物

结构：COC(=O)c1ccc2c(c1)N(CCN1CCC(N)CC1)C(=O)CO2
HCID66774773

未命名化合物

2 次

PRODUCTS

生成物

1
结构：COC(=O)c1ccc2c(c1)N(CCN1CCC(NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)CO2
HCID15981894

未命名化合物

收率 13%

PROCEDURE

实验过程

Methyl 4-[2-(4-aminopiperidin-1-yl)ethyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate (Intermediate 84), 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde (WO 2004/058144) and sodium cyanoborohydride were reacted as described under Example 21 to give the product as an off-white solid in 13% yield.