HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 6-Chloro-1-mercapto-4-(4-nitrophenyl)-3,4-dihydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-(3-Chlorophenyl)-2-(4-nitrophenyl)ethyl Isothiocyanate | HCID 86630124 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Chloro-1-mercapto-4-(4-nitrophenyl)-3,4-dihydroisoquinoline | HCID 178526524 | — |
Reaction Steps
1.75 ml of concentrated sulfuric acid were added to 0.4 g (1.255 mmol) of 2-(3-chlorophenyl)-2-(4-nitrophenyl)ethyl isothiocyanate with external ice cooling and internal stirring. Stirring at RT for a further 4 hours was followed by addition of ice-water and extraction with dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124621B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-6828f5afb5bf4c2db57e525ece62aaee |
| Source note | uspto-grants-2012_02 |