HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzoic Acid → HCID 59243104, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzoic Acid | HCID 7420 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromopyridine-2,3-diamine | HCID 691156 | — |
| Reactant | 1-Methyl-1H-imidazole-2-carbonyl chloride | HCID 22646752 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59243104 | HCID 59243104 | — |
Reaction Steps
3-Hydroxybenzoic acid was reacted with N-methyl-2-imidazoylchloride in the presence of potassium carbonate in dimethylformamide to produce the ether adduct as shown. Subsequent reactions as described previously with 5-bromo-2,3-diaminopyridine followed by microwave reaction gave the final product. 1H NMR (400 MHz, CDCl3) δ ppm 8.37 (s, 1H), 8.09 (s, 1H), 7.84 (s, 1H), 7.35 (m, 3H), 6.95 (m, 1H), 6.87 (m, 1H), 6.73 (m, 1H), 5.30 (s, 2H), 2.25 (s, 3H); Calc'd for C17H14BrN5O; m/z (M+2H+)=385; found 385.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124617B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-e9a9c8b8534c492a9cd8eec4ec1a5674 |
| Source note | uspto-grants-2012_02 |