反应详情

To a suspension of 3-(chloromethyl)-N-methyl-benzamide (27.2 g, 148 mmol) in toluene (100 mL) was added thionyl chloride (16.2 mL, 222 mmol) at room temperature. The resulting suspension was heated at reflux for 15 hours. The reaction mixture was cooled to room temperature and then concentrated under vacuum. The residue was azeotroped with toluene and dried under high vacuum. To a suspension of sodium azide (11.6 g, 178 mmol) in acetonitrile (140 mL) was added chlorotrimethylsilane (23.7 mL, 187 mmol) at room temperature and the suspension was stirred for 1.5 hours. The reaction mixture was cooled to −10° C. and the above crude imidoyl chloride (148 mmol) in acetonitrile (40 mL) was added over 5 minutes. The mixture was stirred for 2 hours at 0° C. and then stirred at room temperature for 15 hours. The reaction mixture was diluted with water (200 mL) and extracted with ethyl acetate (2×100 mL). The combined organic extracts were washed with brine and dried over anhydrous magnesium sulfate. Filtration and concentration gave a light yellow solid which was dissolved in hexanes-ethyl acetate (220 mL, 11:9 ratio) at 60-70° C. The resulting solution was stored in the refrigerator and the precipitated solids were collected by filtration and washed with hexanes. After drying in air, 3-(1-methyltetrazol-5-yl)benzyl chloride was isolated as 24.5 g (79.5%) of a white amorphous solid, mp 63-65° C.; HRMS (ES+) cald. for C9H9ClN4 [(M+H)+] 209.0589, obsd. 209.0588.

1. temperatureThe resulting suspension was heated
2. temperatureat reflux for 15 hours
3. concentrationconcentrated under vacuum
4. customThe residue was azeotroped with toluene
5. customdried under high vacuum
6. temperatureThe reaction mixture was cooled to −10° C.
7. stirringThe mixture was stirred for 2 hours at 0° C.
8. stirringstirred at room temperature for 15 hours
9. extractionextracted with ethyl acetate (2×100 mL)
10. washThe combined organic extracts were washed with brine
11. dry with materialdried over anhydrous magnesium sulfate
12. filtrationFiltration and concentration
13. customgave a light yellow solid which
14. dissolutionwas dissolved in hexanes-ethyl acetate (220 mL, 11:9 ratio) at 60-70° C
15. filtrationthe precipitated solids were collected by filtration
16. washwashed with hexanes
17. customAfter drying in air