反应详情

温度

50 °C

2-(1,3-thiazol-2-ylcarbamoyl)phenyl acetate (501, 663.3 mg, 2.53 mmol) was added to a 25 mL round bottom flask equipped with a stirbar and a water-jacketed condenser. The headspace was replaced with dry nitrogen, and concentrated hydrochloric acid (15.0 mL) was added in a single portion. The suspension was heated to 50° C., and stirred well. The suspended solids dissolved to form a clear colorless solution before solids precipitate from the reaction mixture, which was then cooled in an ice bath, and the solids were filtered on a medium frit and washed with a large portion of water. The filter cake wash washed through the frit with methanol, collected, and the solvent was removed in vacuo to give 502 (481.5 mg, 86%) as a colorless solid.

1. customequipped with a stirbar and a water-jacketed condenser
2. additionwas added in a single portion
3. dissolutionThe suspended solids dissolved
4. customto form a clear colorless solution before solids
5. customprecipitate from the reaction mixture, which
6. temperaturewas then cooled in an ice bath
7. filtrationthe solids were filtered on a medium frit
8. washwashed with a large portion of water
9. washThe filter cake wash
10. washwashed through the frit with methanol
11. customcollected
12. customthe solvent was removed in vacuo